H. FRANKLIN HERLONG, M.D.; PHILIP R. REID, M.D.; JOHN K. BOITNOTT, M.D.; WILLIS C. MADDREY, M.D., F.A.C.P.
We have seen two patients whose hepatitis was due to the administration of aprindine, a new antiarrhythmic agent. In both patients evidence of hepatitis appeared within 3 weeks of initiating aprindine therapy and resolved rapidly when the drug was withdrawn. The reintroduction of aprindine in one patient was associated with the reappearance of hepatitis, which resolved despite continued administration of the drug.
HERLONG HF, REID PR, BOITNOTT JK, MADDREY WC. Aprindine Hepatitis. Ann Intern Med. ;89:359–361. doi: 10.7326/0003-4819-89-3-359
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Published: Ann Intern Med. 1978;89(3):359-361.
Gastroenterology/Hepatology, Liver Disease.
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