GARY P. STOEHR, Pharm.D.; ANN L. PETERSON, M.D.; WILLIAM J. TAYLOR, Pharm.D.
Although thrombocytopenia and leukopenia have occurred after treatment with the investigational antineoplastic agent epipodophyllotoxin (VM-26) (1), bone marrow toxicity has not been observed after treatment with the parent compound podophyllin. We have recently observed a case of leukopenia and thrombocytopenia resulting from local podophyllin (podophyllum resin) treatment of condyloma acuminata.
A 15-year-old black girl was admitted to Duke Hospital on 14 September 1977 for surgical excision of congenital cutaneous nevi of the left arm and leg. With the exception of a linear cutaneous nevus and the presence of a large fungating growth involving the inner aspect of the upper left
STOEHR GP, PETERSON AL, TAYLOR WJ. Systemic Complications of Local Podophyllin Therapy. Ann Intern Med. ;89:362–363. doi: 10.7326/0003-4819-89-3-362
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Published: Ann Intern Med. 1978;89(3):362-363.
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