MING-JIANG WU, M.D.; THOMAS A. NARSETE, M.D.; JOHN L. HUSSEY, M.D.; ARVIN B. WEINSTEIN, M.D.; SUNG-FENG WEN, M.D.
To the editor: In a recent article, "Drug-Related Syndromes in Clinical Nephrology", Bennett, Plamp, and Porter (1) pointed out that high-dose penicillin may produce seizures, altered mental state, and myoclonic jerking in uremic patients. We would like to add that another group of widely used antibiotics, the cephalosporins, can cause a similar syndrome. We recently saw a patient who developed severe encephalopathy due to accumulation of cephalothin.
A 46-year-old white man with uremia received intravenous cephalothin, 4 to 5 g/day, after bilateral nephrectomy for infection in polycystic kidneys. During surgery 6 g of cephalothin was instilled in the abdominal cavity.
WU M, NARSETE TA, HUSSEY JL, WEINSTEIN AB, WEN S. Cephalothin Neurotoxicity in Renal Failure. Ann Intern Med. ;89:429. doi: 10.7326/0003-4819-89-3-429_1
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Published: Ann Intern Med. 1978;89(3):429.
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