JACOB J. LOKICH, M.D.
To the editor: The report by Shani and colleagues (1) on the use of serial measurements of plasma carcinoembryonic antigen (CEA) in patients with colorectal cancer has major clinical implications for the practicing oncologist, and the article should be carefully reviewed by all clinicians.
The authors seem to be ambivalent with regard to the use of CEA, stating in the adverse column that CEA levels were not predictive of subsequent tumor response; were discordant in a "substantial" proportion of patients; were not correlated with patient survival; and were no more useful than the more simply and economically measured serum alkaline
LOKICH JJ. Carcinoembryonic Antigen and Monitoring of Metastatic Colorectal Carcinoma. Ann Intern Med. ;89:573. doi: 10.7326/0003-4819-89-4-573
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Published: Ann Intern Med. 1978;89(4):573.
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