RICHARD S. FARR, M.D.; SHELDON L. SPECTOR, M.D.; CAROLYN WANGAARD, R.N.
To the editor: We read with interest the case report of Daniel Kordansky and colleagues (Ann Intern Med 88:508-511, 1978) "Asthma Improved by Nonsteroidal Anti-Inflammatory Drugs".
For the past 5 years at National Jewish Hospital, we have challenged a great many asthmatic patients with aspirin, placebo, tartrazine, sodium salicylate, and acetaminophen. Of 230 aspirin challenges, 44 or 19% led to significant bronchospasm. We found only one patient or 0.4% who was helped by aspirin. Unlike the authors, we did not test that patient with indomethacin, mefanamic acid, ibuprofen, or phenylbutazone. When historical information on aspirin idiosyncrasy is gathered, one obtains
FARR RS, SPECTOR SL, WANGAARD C. Asthma and Nonsteroidal Anti-inflammatory Drugs. Ann Intern Med. ;89:577–578. doi: 10.7326/0003-4819-89-4-577_2
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Published: Ann Intern Med. 1978;89(4):577-578.
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