JOSIAH BROWN, M.D.; WILLIAM R. CLARK, Ph.D.; RHODA K. MAKOFF, Ph.D.; HARRY WEISMAN, M.D.; JOHN A. KEMP, B.A.; YOKO MULLEN, M.D., Ph.D.
Despite the best efforts of physicians and diabetic patients in the use of insulin for control of juvenile-onset (insulin-deficient) diabetes, vascular complications occur in most patients. The many advantages of the whole fetal pancreas as a donor organ make transplantation of the pancreas a promising improvement in therapy. A rat model has been developed for future application to human beings. After transplantation of one fetal rat pancreas into a diabetic recipient, maturation and growth of the transplant is adequate for complete reversal of the diabetic state of the recipient. Because of the atrophy of exocrine elements after transplantation of the fetal organ, many of the technical problems inherent in adult pancreas transplants are avoided. The small size of the fetal pancreas permits cryopreservation and permanent storage without apparent loss of function. Cryopreservation provides time for typing, matching, and preparation of the recipient to receive the donor organ and thus may alleviate rejection problems.
BROWN J, CLARK WR, MAKOFF RK, WEISMAN H, KEMP JA, MULLEN Y. Pancreas Transplantation for Diabetes Mellitus. Ann Intern Med. ;89:951–965. doi: 10.7326/0003-4819-89-6-951
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Published: Ann Intern Med. 1978;89(6):951-965.
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