OSVALDO HÜBSCHER, M.D.; OSVALDO GARCÍA-MORTEO, M.D.; ROBERT M. ARANA, M.D.
To the editor: Rothfield, Bierer, and Garfield state in a recent issue (1) that isoniazid alone or in combination is a potent inducer of antinuclear antibodies (ANA); in their prospective study 22% of 102 tuberculosis patients developed ANA after at least 1 month of treatment. In a prospective study, Siegel, Lee, and Peress (2) found no evidence of an increase of ANA after prolonged isoniazid therapy in 29 patients, but this result was regarded as inconclusive because of the small sample size.
We have found ANA by indirect immunofluorescence in 6% of 80 isoniazid-treated tuberculosis patients at a mean dose
HÜBSCHER O, GARCÍA-MORTEO O, ARANA RM. Isoniazid and Antinuclear Antibodies. Ann Intern Med. ;89:1011. doi: 10.7326/0003-4819-89-6-1011_1
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Published: Ann Intern Med. 1978;89(6):1011.
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