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Selective immune responsiveness to a host's native antigens was of great concern to early pioneers of immunology. Indeed, Ehrlich's phrase of "horror autotoxicus" seemed to be a logical explanation of this phenomenon and gained general credence among immunologists for many years. It was not until the discovery of incomplete Rh antibodies by Coombs, Mourant, and Race in 1945 that the production of antibodies against self-constituents was even considered possible. Since then, of course, the pathologic significance of autoimmunity has been widely appreciated in many human diseases. In the past decade scientific progress in this specialty of immunology has been especially
Autoimmunity.. Ann Intern Med. ;89:1016. doi: 10.7326/0003-4819-89-6-1016_2
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Published: Ann Intern Med. 1978;89(6):1016.
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