JOHN L. ABRUZZO, M.D.
The treatment of systemic sclerosis has been ineffectual despite past enthusiasm for some drugs, notably corticosteroids, dimethyl sulfoxide, epsilon aminocaproic acid, potassium para-amino benzoic acid, and edetate disodium. Recent reports have brought promise of advances in management. The results of renal transplantation have been better than expected (1-3). D-Pencillamine may be effective in early disease (4-6), and the previously inevitable fatal outcome for the patient with severe renal failure and hypertension seems to be reversible with antihypertensive therapy and chronic renal dialysis (7-9).
Diagnosis of scleroderma is rarely difficult in its advanced form. The clinician readily recognizes typical leathery and
ABRUZZO JL. Some Progress with Systemic Sclerosis. Ann Intern Med. ;90:117–118. doi: 10.7326/0003-4819-90-1-117
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Published: Ann Intern Med. 1979;90(1):117-118.
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