RICHARD S. STEIN, M.D.
To the editor: Torosian and colleagues (1) have reported increased postoperative bleeding in patients receiving aspirin within a week of surgery. Although the effects of aspirin last for the lifetime of exposed platelets, 5 to 7 days, the bleeding time is normal within 2 days after administration of aspirin (2, 3), and platelets collected from donors receiving aspirin 36 h before donation can correct abnormal bleeding times in recipients (4). Although aspirin-exposed platelets do not release their own ADP, if sufficient normal platelets are present the entire platelet pool appears to function normally, at least as measured by bleeding time.
STEIN RS. Aspirin and Postoperative Bleeding. Ann Intern Med. 1979;90:123. doi: 10.7326/0003-4819-90-1-123_1
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Published: Ann Intern Med. 1979;90(1):123.
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