HARRY L. ARNOLD JR., M.D.
To the editor: The recommendation by Stoehr, Peterson, and Taylor (1) that podophyllin toxicity be prevented by limiting applications to small areas of intact skin is totally unrealistic; what good could that possibly do to a condyloma acuminatum? Their recommendation that the drug be removed after 1 h is also unrealistic; 4 to 6 h is a minimum time, and condylomas that have a pretty stout epithelial covering may require that it be left on for 12 to 24 h.
What they should have recommended is that a "large" condyloma—one measuring, let us say, in excess of 10 to 20
ARNOLD HL. Podophyllin Therapy. Ann Intern Med. ;90:133–134. doi: 10.7326/0003-4819-90-1-133_2
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Published: Ann Intern Med. 1979;90(1):133-134.
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