J. EDWARD BERK, M.D.; LOUIS FRIDHANDLER, Ph.D.; RUSSELL L. NESS, M.D.
Impaired renal function may be associated with rises in serum amylase activity (1-5) and the ratio of amylase clearance to creatinine (Cam/Ccr) (3, 4, 6). These deviations cloud the interpretation of abdominal pain and hyperamylasemia in patients with chronic renal disease as indicators of complicating acute pancreatitis (5). This study is primarily concerned with the effect of marked renal impairment on the serum activities and relative urinary clearances of the pancreatic-type (P-type) and salivary-type (S-type) isoenzymes of amylase about which information is limited at present (3).
The study group was composed of 36 patients with advanced renal insufficiency. Twenty-four were
BERK JE, FRIDHANDLER L, NESS RL. Amylase and lsoamylase Activities in Renal Insufficiency. Ann Intern Med. ;90:351–353. doi: 10.7326/0003-4819-90-3-351
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Published: Ann Intern Med. 1979;90(3):351-353.
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