MURRAY A. VARAT, M.D.
To the editor: The association between lupus myositis and myocarditis reported by Borenstein and co-workers in the November issue (1) is very interesting. I wish to comment on the significance of the serum creatine kinase (CK)-cardiac (MB) isoenzyme elevation in their patient and on their suggestion that CK isoenzyme determination may be of value in the diagnosis of lupus myocarditis.
A small amount of CK-MB is found in skeletal muscle by tissue analyses (2). In addition, in healthy control subjects, up to 2% of serum CK may be in the MB form (3). Therefore, the total CK of 1730 U/litre
VARAT MA. Myocarditis of Lupus Erythematosus. Ann Intern Med. ;90:438–439. doi: 10.7326/0003-4819-90-3-438
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Published: Ann Intern Med. 1979;90(3):438-439.
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