RONALD J. FALLON, M.D.; WILLIAM H. ABRAHAM
Four-hundred fifty-nine sera from 342 persons were examined at Ruchill Hospital, Glasgow, using an agargrown heat-killed, ether-treated antigen derived from the Philadelphia 1 strain of the Legionnaires' disease bacterium. They were examined, in parallel, at the Center for Disease Control (CDC), Atlanta. Overall agreement (results agreeing ± one twofold dilution) was reached with 90% of sera. Important differences were obtained with 10 (2.2%) sera. With three of these 10 sera the CDC alone obtained a significant titre (256) whereas with the other seven the Glasgow laboratory alone obtained a titre of 256. Altogether 28 persons (8.2%) with an agreed titre of 256 or higher were identified. However, some of these people had been ill 4 years before serum was obtained for examination. These persistent high titres make the serologic diagnosis of Legionnaires' disease difficult.
FALLON RJ, ABRAHAM WH. Scottish Experience with the Serologic Diagnosis of Legionnaires' Disease. Ann Intern Med. 1979;90:684–686. doi: 10.7326/0003-4819-90-4-684
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Published: Ann Intern Med. 1979;90(4):684-686.
Infectious Disease, Pulmonary/Critical Care.
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