N. C. THOMSON; B. RANA; J. G. RATCLIFFE
To the editor: The role, if any, of the carcinoembryonic antigen (CEA) assay in differentiating malignant from benign pleural effusions is not yet clear, despite several recent reports on the subject (1-4). The confusion is due in part to the variety of criteria that have been used to assess diagnostic sensitivity and specificity of the CEA test on pleural effusions. We suggest that a clinically realistic assessment can be obtained by expressing test sensitivity in terms of the proportion of malignant aspirates with CEA levels above the range observed in benign aspirates. This eliminates problems of false-positives in the benign
N. C. THOMSON, B. RANA, J. G. RATCLIFFE. Carcinoembryonic Antigen Assay in Pleural Effusions. Ann Intern Med. 1979;90:720–721. doi: 10.7326/0003-4819-90-4-720
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Published: Ann Intern Med. 1979;90(4):720-721.
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