HENRY G. KAPLAN, M.D.; JOHAN BAKKEN, M.D.; LEONARD QUADRACCI, M.D.; WILLIAM SCHUBACH, M.D.
Halothane has been identified as the cause of hypersensitivity-mediated hepatitis (1). Repeated use of this agent has frequently caused hepatotoxicity in humans (2, 3) and laboratory animals (4-7). We recently cared for three patients who developed hepatitis after repeated sniffing of halothane to produce a drug "high."
Patient 1, a thin, 25-year-old Mexican female scrub technician at a local hospital, complained of sore throat, headaches, malaise, nausea, vomiting, and fever of 40 °C. Three days later she was admitted to the hospital where her temperature was 34.5 °C, blood pressure 128/70 mm Hg, and pulse 100 beats/min and irregular. Jaundice
KAPLAN HG, BAKKEN J, QUADRACCI L, SCHUBACH W. Hepatitis Caused by Halothane Sniffing. Ann Intern Med. ;90:797–798. doi: 10.7326/0003-4819-90-5-797
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Published: Ann Intern Med. 1979;90(5):797-798.
Gastroenterology/Hepatology, Liver Disease.
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