WILLIAM A. BLATTNER, M.D.; JACK H. DEAN, Ph.D.; JOSEPH F. FRAUMENI Jr., M.D.
In 1969 we reported an aggregation of chronic lymphocytic leukemia in three siblings, together with immune defects that may have contributed to the familial predisposition (1). This follow-up study extends the range of B-cell neoplasms and immune defects occurring in this family (Figure 1).
In 1974, the 42-year-old daughter (III-2) of the proband developed stage III-A, nodular, poorly differentiated lymphocytic lymphoma, which responded to cyclophosphamide, vincristine, and prednisone. She relapsed in June 1978 and responded to a second course of the same drugs. As a child, numerous vaccinations were unsuccessful; but subsequently, she showed no unusual susceptibility to infection.
BLATTNER WA, DEAN JH, FRAUMENI JF. Familial Lymphoproliferative Malignancy: Clinical and Laboratory Follow-Up. Ann Intern Med. ;90:943–944. doi: 10.7326/0003-4819-90-6-943
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Published: Ann Intern Med. 1979;90(6):943-944.
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