ROBERT G. GRAY, M.D.; MARTIN J. POPPO, M.D.; NORMAN L. GOTTLIEB, M.D.
We identified bilateral carpal tunnel syndrome in 19 of 43 living persons of a nonconsanguineous family. No single common etiologic feature was seen. Sixty-three percent of the afflicted kindred had symptomatic digital flexor tenosynovitis. Noninflammatory thickening of the flexor retinaculum or tendon sheaths, or both, was the commonest surgical finding. The 44% prevalence, early age of onset, and equal sex ratio differ from idiopathic carpal tunnel syndrome. Family pedigree suggests an inheritable disorder transmitted by an autosomal dominant gene with a high degree of penetrance.
GRAY RG, POPPO MJ, GOTTLIEB NL. Primary Familial Bilateral Carpal Tunnel Syndrome. Ann Intern Med. ;91:37–40. doi: 10.7326/0003-4819-91-1-37
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Published: Ann Intern Med. 1979;91(1):37-40.
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