LOUIS Y. KORMAN, M.D.; J. ROBERT SMITH, M.D.; STEPHEN A. LANDAW, M.D., Ph.D.; FREDERICK R. DAVEY, M.D.
Bone marrow failure as a result of marrow involvement has been considered the major cause of pancytopenia in patients with Hodgkin's disease. We describe here the case of a patient with lymphocyte-depletion Hodgkin's disease in which the destruction of blood elements by intramedullary macrophages resulted in severe, refractory pancytopenia.
A 62-year-old white man presented with a 2-month history of night sweats and weight loss. At physical examination he was icteric; his temperature was 38 °C, pulse 90/min, respiratory rate 16/min, and blood pressure 90/60 mm Hg. Liver span measured 13 to 14 cm; the spleen tip was palpable. Ascites and
KORMAN LY, SMITH JR, LANDAW SA, DAVEY FR. Hodgkin's Disease: Intramedullary Phagocytosis with Pancytopenia. Ann Intern Med. ;91:60–61. doi: 10.7326/0003-4819-91-1-60
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Published: Ann Intern Med. 1979;91(1):60-61.
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