ROBERT L. BREARLEY, M.B.; RAMONA M. CHAPMAN, M.D.; BRANCO BROZOVIC, Ph.D.
Hairy-cell leukemia typically presents with a reduction in normal peripheral blood cells and variable numbers of circulating mononuclear cells with prominent cytoplasmic projections. The blood changes are usually associated with effacement of bone-marrow architecture by a diffuse mononuclear cell infiltrate and a characteristic pattern of increased delicate fibrosis seen on marrow
biopsy (1-3). During the past 3 years, four patients with hairy-cell leukemia have been referred to our departments with peripheral blood cytopenias but bone-marrow hypoplasia of such degree that they were originally diagnosed as having aplastic anemia. This presentation has not been described previously.
Three patients presented with anemia
BREARLEY RL, CHAPMAN RM, BROZOVIC B. Hairy-Cell Leukemia Presenting as Aplastic Anemia. Ann Intern Med. ;91:228. doi: 10.7326/0003-4819-91-2-228
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Published: Ann Intern Med. 1979;91(2):228.
Hematology/Oncology, Leukemia/Lymphoma, Red Cell Disorders.
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