PAUL MITNICK, M.D.; RICHARD STERNS, M.D.; MALCOLM COX, M.D.
To the editor: De Fronzo and associates in the March 1979 issue (1) have described a K+ secretory defect in six patients with sickle-cell hemoglobinopathy but hyperkalemia (even during acute and chronic potassium loading) was notably absent. However, these authors made note of an abstract (2) describing hyperkalemia in a patient with sickle-cell hemoglobinopathy and commented that they have seen a chronically hyperkalemic patient with HbSS disease. We have recently studied a patient with documented HbSS disease who developed life-threatening hyperkalemia while receiving only modest amounts of potassium.
A 25-year-old black woman underwent cesarean section at 36 weeks with uncomplicated
MITNICK P, STERNS R, COX M. Potassium Tolerance in Sickle-Cell Hemoglobinopathy. Ann Intern Med. ;91:319–320. doi: 10.7326/0003-4819-91-2-319
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Published: Ann Intern Med. 1979;91(2):319-320.
Hematology/Oncology, Red Cell Disorders.
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