ROBERT J. LEFKOWITZ, M.D.
Recently developed radioligand binding techniques permit direct investigation of the alpha- and beta-adrenergic receptors for catecholamines in a wide variety of tissues. These techniques allow the receptors to be quantitated, characterized, and studied under varying conditions of physiologic and pathophysiologic interest. They are providing fresh insights into the mechanisms by which endogenous catecholamines and other hormones regulate the properties of the adrenergic receptors and, in turn, control tissue sensitivity to catecholamine action.
LEFKOWITZ RJ. Direct Binding Studies of Adrenergic Receptors: Biochemical, Physiologic, and Clinical Implications. Ann Intern Med. ;91:450–458. doi: 10.7326/0003-4819-91-3-450
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Published: Ann Intern Med. 1979;91(3):450-458.
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