MICHAEL L. LEVIN, M.D.
To the editor: I read with interest the article in the May issue "Single or Combination Therapy of Staphylococcal Endocarditis in Intravenous Drug Abusers" (1). I am particularly concerned that there was no mention of serumcidal or mean bactericidal concentration. We, too, have been concerned as to whether acute staphylococcal endocarditis could be better treated with single-drug or combination-drug therapy. In our experience, two recent cases in addicts were treated initially with a combination of semisynthetic penicillin and an aminoglycoside. Serumcidal studies pretherapy of 1:8 with demonstration of synergism using a combination of a semisynthetic penicillin and aminoglycoside prompted us
LEVIN ML. Antibiotic Therapy of Staphylococcal Endocarditis. Ann Intern Med. ;91:492–493. doi: 10.7326/0003-4819-91-3-492_2
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Published: Ann Intern Med. 1979;91(3):492-493.
Cardiology, Endocarditis, Infectious Disease.
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