IRVING H. GOMOLIN, M.D.
To the editor: Gershon and associates' brief report of propranolol inducing psychosis at ordinary doses (1) is timely since new indications for its use (hypertension, migraine) have been approved. Several points, however, deserve comment.
The authors state that toxic psychosis generally occurs with high doses. This statement is somewhat misleading since this effect may be related more to the rate of increase rather than to the total daily dose (2) and may have been the cause for the psychosis in their patient. In addition, the two thyrotoxic patients described in the literature who developed psychosis did so at ordinary doses,
GOMOLIN IH. Psychosis with Oral Doses of Propranolol. Ann Intern Med. ;91:496. doi: 10.7326/0003-4819-91-3-496_1
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Published: Ann Intern Med. 1979;91(3):496.
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