JAMES M. FALKO, M.D.; JOSEPH L. WITZTUM, M.D.; GUSTAV SCHONFELD, M.D.; JOYCE BATEMAN, R.D.
Recent epidemiologic and experimental data suggest that high-density lipoproteins may protect against the development of atherosclerosis (1, 2). Cross-sectional population studies have shown that plasma triglyceride values are inversely related to high-density lipoprotein-cholesterol values in both normal and hyperlipidemic populations (3). This has led to the suggestion that therapeutic lowering of plasma triglyceride levels would result in elevation of high-density lipoprotein-cholesterol levels. However, in a prospective longitudinal study of subjects with type IV hyperlipoproteinemia, we have shown that hypocaloric diet-induced normalization of plasma triglyceride levels failed to correct their initially low high-density lipoprotein-cholesterol values (4). In contrast, in response to
FALKO JM, WITZTUM JL, SCHONFELD G, BATEMAN J. Dietary Treatment of Type V Hyperlipoproteinemia Fails to Normalize Low Levels of High-Density Lipoprotein Cholesterol. Ann Intern Med. ;91:750–751. doi: 10.7326/0003-4819-91-5-750
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Published: Ann Intern Med. 1979;91(5):750-751.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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