RICHARD L. ELTON, PH.D.; HARRISON M. LANGRALL, M.D.
To the editor: The excellent and valuable review in the June issue by Drs. Spark and Dickstein, "Bromocriptine and Endocrine Disorders" (1), referred to the potential teratogenicity of this drug in humans because of the occurrence of "cleft lip" in the offspring of rabbits treated during pregnancy. We believe it is important for the assessment of the risks and benefits of any drug that full information be presented. To this end, we include the data on cleft palates from five studies in rabbits. The reader is also referred to the package insert for Parlodel® (bromocriptine mesylate; Sandoz Inc., East Hanover,
ELTON RL, LANGRALL HM. Is Bromocriptine Teratogenic?. Ann Intern Med. ;91:791. doi: 10.7326/0003-4819-91-5-791_1
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Published: Ann Intern Med. 1979;91(5):791.
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