ROBERT J. MASI, M.D.; G. RICHARD O'CONNOR, M.D.
To the editor: We have read with interest the recent correspondence (1) reporting a presumptive anterior uveitis without apparent retinochoroiditis in acquired toxoplasmosis.
Although there is now little doubt that the acquired disease can result in a retinochoroiditis (2-4), an isolated anterior uveitis caused by toxoplasmosis remains speculative. The anterior chamber reaction that commonly accompanies the retinochoroiditis observed in both congenital and acquired toxoplasmosis is thought to represent a "spillover" phenomenon, that is, a hypersensitivity reaction in the anterior uvea (iris and ciliary body) to an antigenic insult in the posterior segment (5). This reaction has been experimentally produced in
MASI RJ, O'CONNOR GR. Toxoplasma Uveitis Without Retinochoroiditis?. Ann Intern Med. ;91:793–794. doi: 10.7326/0003-4819-91-5-793_4
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Published: Ann Intern Med. 1979;91(5):793-794.
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