JOHN G. CURD, M.D.; HENRY MILGROM, M.D.; DONALD D. STEVENSON, M.D.; DAVID A. MATHISON, M.D.; JOHN H. VAUGHAN, M.D.
During metabolism studies of radiolabeled proteins in 126 participants four patients were suspected of being sensitive to potassium iodide (KI) because they repeatedly developed urticaria and other symptoms after KI administration. Two of the four patients suspected of KI sensitivity and 10 control patients were orally challenged with KI to document and characterize KI sensitivity and to evaluate the possible association(s) of KI sensitivity with urticaria, hypocomplementemia, and vasculitis. The KI challenges in the two sensitive patients precipitated urticaria, angioedema, polymyalgias, conjunctivitis, and coryza. One of these two patients also developed a severe systemic illness characterized by fever, headache, peritonitis, episcleritis, and pneumonitis. The four sensitive patients were strikingly similar in that they exhibited hypocomplementemia and dermal vasculitis associated with chronic urticaria or systemic lupus erythematosus, suggesting that other patients with similar clinical features may be sensitive to KI and that KI may precipitate severe systemic illness in them.
CURD JG, MILGROM H, STEVENSON DD, MATHISON DA, VAUGHAN JH. Potassium Iodide Sensitivity in Four Patients with Hypocomplementemic Vasculitis. Ann Intern Med. ;91:853–857. doi: 10.7326/0003-4819-91-6-853
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Published: Ann Intern Med. 1979;91(6):853-857.
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