JAMES W. MOSLEY, M.D.
The discovery at the end of the 1960s that the Australia antigen (now called hepatitis B surface antigen [HBsAg]) is a component of hepatitis B virus (HBV) opened the door to preparation of hepatitis B immune globulin (HBIG) having titers of specific antibody (anti-HBs) many hundredfold times higher than those in standard immune serum globulin (ISG). As rapidly as anti-HBs-rich units of plasma could be identified and batches of HBIG prepared, studies of prophylaxis of type B hepatitis were carried out (1-6). Unfortunately, these investigations did not provide an easily interpretable answer to relative usefulness of HBIG and ISG. Hence,
JAMES W. MOSLEY. Hepatitis B Immune Globulin: Some Progress and Some Problems. Ann Intern Med. 1979;91:914–916. doi: 10.7326/0003-4819-91-6-914
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Published: Ann Intern Med. 1979;91(6):914-916.
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