LOREN I. DOLMAN, M.D.
To the editor: The report of Wortsman and colleagues in the June issue (1) concludes that cyproheptadine in a dose of 16 to 24 mg/d for 8 to 16 weeks can effectively lower serum prolactin (PRL) levels and decrease symptomatic galactorrhea in patients with the galactorrhea-amenorrhea syndrome.
In 1976 we were interested in the antiserotonin properties of cyproheptadine, noting evidence that serotonin probably plays a role in the release of pituitary PRL, growth hormone, and ACTH, as well as suppression of thyroid-stimulating hormone, luteinizing hormone, and follicle-stimulating hormone. The effects of the drug in suppressing ACTH release in Cushing's disease
DOLMAN LI. Cyproheptadine Effects on Pituitary Function. Ann Intern Med. ;91:927. doi: 10.7326/0003-4819-91-6-927_1
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Published: Ann Intern Med. 1979;91(6):927.
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