DONATO FUMAROLA, M.D.
To the editor: We agree with the statement of Viallet and Villeneuve (1) about a close connection between intravascular coagulation and ascitic fluid infusion. We would like to indicate a possible pathogenetic mechanism for these disorders. Recent investigations have demonstrated that ascitic fluid can contain variable amounts of endotoxin, detected by the Limulus assay (GOLDBERG PK, KOZINN PJ, GROSSBERG SJ, WAPNICK S, LUPOVICI M. Increased endotoxemia following the LeVeen peritoneovenous shunt. 78th Annual Meeting of the American Society for Microbiology, Las Vegas, 14-19 May 1978. Abstract ct B 56). Because ascitic fluid exhibits procoagulant properties (PHILLIPS LL, RODGERS JB. Procoagulant
FUMAROLA D. Intravascular Coagulation, Ascitic Fluid Infusion, and Endotoxin. Ann Intern Med. ;91:929. doi: 10.7326/0003-4819-91-6-929_1
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Published: Ann Intern Med. 1979;91(6):929.
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