IGNAC FOGELMAN, M.B., Ch.B; RODNEY G. BESSENT, M.A., D.Phil.; GRAHAM BEASTALL, Ph.D.; IAIN T. BOYLE, M.B., Ch.B.
The 24-h whole-body retention of technetium-99m diphosphonate was elevated in 16 patients with primary hyperparathyroidism (mean whole body retention, 50.6%, compared to controls, 19.4%), with each result out of the control range. There was a rank correlation between whole-body retention and plasma parathyroid hormone (r = 0.86, P < 0.001) but the correlation with serum alkaline phosphatase and calcium values was less significant (r = 0.58, P < 0.05 in each case). Repeat studies of whole body retention performed in five patients before and after parathyroidectomy showed a fall to normal or near normal values. Measurement of 24-h whole-body retention of diphosphonate is a simple, sensitive test to aid in the diagnosis and evaluation of patients with primary hyperparathyroidism. The test could be used as a screening procedure in patients with recurrent renal stones, for example, or to assess the extent of skeletal involvement in patients with an established diagnosis.
FOGELMAN I, BESSENT RG, BEASTALL G, BOYLE IT. Estimation of Skeletal Involvement in Primary Hyperparathyroidism: Use of 24-Hour Whole-Body Retention of Technetium-99m Diphosphonate. Ann Intern Med. ;92:65–67. doi: 10.7326/0003-4819-92-1-65
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Published: Ann Intern Med. 1980;92(1):65-67.
Endocrine and Metabolism, Parathyroid Disorders.
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