KIERTISIN DHARMSATHAPHORN, M.D.; ROBERT S. SHERWIN, M.D.; SAMUEL CATALAND, M.D.; BERNARD JAFFE, M.D.; JOHN DOBBINS, M.D.
Recent studies in rats indicate that somatostatin inhibits jejunal fluid secretion induced by prostaglandin E1 and theophylline in vivo (1) and the effect of vasoactive intestinal polypeptide on fluid transport in the colon in vitro (2). These findings suggest that somatostatin may ameliorate symptoms in patients with watery diarrhea syndromes by suppressing hormonal release or by blocking intestinal secretagogue effects. We report here that somatostatin has inhibited watery diarrhea in a patient with the carcinoid syndrome.
A 64-year-old white woman with metastatic carcinoid tumor had a 5-year history of continuous refractory watery diarrhea. Examination revealed facial telangiectasia and hepatomegaly. All
DHARMSATHAPHORN K, SHERWIN RS, CATALAND S, JAFFE B, DOBBINS J. Somatostatin Inhibits Diarrhea in the Carcinoid Syndrome. Ann Intern Med. ;92:68–69. doi: 10.7326/0003-4819-92-1-68
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Published: Ann Intern Med. 1980;92(1):68-69.
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