KEITH G. TOLMAN, M.D.
Nitrofurantoin is a furan derivative commonly used as a urinary tract antiseptic. It is estimated that approximately 5 million courses of nitrofurantoin or one of its analogs are given yearly in the United States and Canada (Personal communication, Norwich-Eaton Pharmaceuticals, Norwich, New York). Many different side-effects, including fever, leukopenia, hemolytic anemia, pulmonary fibrosis, peripheral neuropathy and cholestatic jaundice have been described. The reports by Black and associates (1) and Sharp and associates (2) in this issue focus on the previously rarely recognized syndrome of nitrofurantoin-induced chronic active hepatitis. Proof of drug-induced injury has been obtained by the ultimate test of
TOLMAN KG. Nitrofurantoin and Chronic Active Hepatitis. Ann Intern Med. ;92:119–120. doi: 10.7326/0003-4819-92-1-119
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Published: Ann Intern Med. 1980;92(1):119-120.
Gastroenterology/Hepatology, Liver Disease.
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