ROBERT L. BARBIERI, M.D.
To the editor: In a recent issue Wortsman and associates (1) reported that women receiving 400 to 800 mg of danazol daily have a low thyroxine (T4) index and normal thyrotropin (TSH) levels. They concluded that some women receiving danazol might be hypothyroid. Their observations do not support their conclusion. Detailed analysis of the effects of danazol on thyroid function indices has shown that danazol lowers thyroxine-binding globulin (TBG) capacity, lowers total T4, and produces no change in free T4 (hence the normal TSH) (2). One explanation of these thyroid function indices is that the androgenic effects of danazol result
BARBIERI RL. Danazol and Thyroid Function. Ann Intern Med. ;92:133–134. doi: 10.7326/0003-4819-92-1-133_2
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Published: Ann Intern Med. 1980;92(1):133-134.
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