ROBERT F. BERNSTEIN, M.D.
Ibuprofen-related meningitis has been seen infrequently in patients with systemic lupus erythematosus (1-3) but apparently has not been reported in association with mixed connective tissue disease.
A 21-year-old Mexican-American woman developed Raynaud's phenomenon and polyarthritis in February 1979. With salicylates her symptoms were controlled for 6 months until severe arthralgias and myalgias returned. Ibuprofen was prescribed and brought her some relief. A pharyngitis developed and was treated with penicillin. Ibuprofen was withdrawn. Two weeks later, while off all medications, she had a recurrence of arthritis and Ibuprofen was again prescribed. She took a single 400-mg tablet and within 3 hours
BERNSTEIN RF. Ibuprofen-Related Meningitis in Mixed Connective Tissue Disease. Ann Intern Med. ;92:206–207. doi: 10.7326/0003-4819-92-2-206
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Published: Ann Intern Med. 1980;92(2_Part_1):206-207.
CNS Infections, Infectious Disease, Neurology.
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