J. M. BENNETT, M.D.; D. CATOVSKY, M.D.; M. T. DANIEL, M.D.; G. FLANDRIN, M.D.; D. A. G. GALTON, M.D.; H. R. GRALNICK, M.D.; C. SULTAN, M.D.; HARVEY R. GRALNICK, M.D.
To the editor: In 1976 we published proposals for the morphologic classification of the acute leukemias with descriptions of each named entity (1). The description of hypergranular proleukemia (M3 in the classification) was as follows:  The great majority of cells are abnormal promyelocytes, with a characteristic pattern of heavy granulation.  The nucleus varies greatly in size and shape and is often reniform or bilobed.  The cytoplasm of most of the cells is completely occupied by closely packed or even coalescent large granules staining bright pink, red, or purple by Romanovsky dyes. In some cells the cytoplasm is
BENNETT JM, CATOVSKY D, DANIEL MT, FLANDRIN G, GALTON DAG, GRALNICK HR, et al. A Variant Form of Hypergranular Promyelocytic Leukemia (M3). Ann Intern Med. ;92:261. doi: 10.7326/0003-4819-92-2-261
Download citation file:
Published: Ann Intern Med. 1980;92(2_Part_1):261.
Results provided by:
Copyright © 2018 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use