STEVEN MEISEL, PHARM.D.; ROY BROWER, M.D.
To the editor: Adverse reactions to rifampin have been reported to occur in up to 6% of exposed patients (1). These usually consist of mild gastrointestinal disturbances and cutaneous reactions, although significant hepatotoxicity and nephrotoxicity have been reported (2, 3). We wish to report a heretofore undescribed reaction associated with the ingestion of rifampin.
A 15-year-old Navajo girl was brought to the emergency room with progressive lethargy, obtundation, generalized pruritis, and marked facial edemaApproximately 6 hours previously she had ingested an unknown quantity of rifampin in a suicide gesture. Vital signs were normal on admission and remained so throughout the
MEISEL S, BROWER R. Rifampin: A Suicidal Dose. Ann Intern Med. ;92:262–263. doi: 10.7326/0003-4819-92-2-262_3
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Published: Ann Intern Med. 1980;92(2_Part_1):262-263.
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