RICHARD S. MUTHER, M.D.; WILLIAM M. BENNETT, M.D.
Aspirin recently has been reported to produce clinically significant declines in renal blood flow and glomerular filtration rate (1-5). Aspirin-induced inhibition of renal prostaglandin synthesis is thought to be responsible for this effect (5, 6). The most dramatic changes in renal function have been observed in patients with underlying renal diseases, although similar changes have been noted in normal humans (1, 3).
The clinical significance of these changes has been difficult to interpret because previous measurements of the glomerular filtration rate have shown some variability (7) and the study conditions of the subjects have not been precisely defined. We therefore
MUTHER RS, BENNETT WM. Effects of Aspirin on Glomerular Filtration Rate in Normal Humans. Ann Intern Med. ;92:386–387. doi: 10.7326/0003-4819-92-3-386
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Published: Ann Intern Med. 1980;92(3):386-387.
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