G. DAVIS GAMMON, M.D.; HISHAM HAFEZ, M.D.; JOHN P. DOCHERTY, M.D.
To the editor: Phenothiazines have had a well-known salutory impact on the treatment of psychosis. Unfortunately, a large number of schizophrenic patients remain chronically psychotic despite phenothiazine treatment. Assuming an essential similarity of neurochemical pathology, a number of mechanisms have been proposed to account for this refractoriness to drug treatment: noncompliance (1), poor absorption from the gut (2), modified receptor sensitivity (3), and accelerated liver metabolism (4).
Zarrabi and colleagues (5) report an interesting and useful study suggesting a speculation that might shed further light in the problem of phenothiazine resistance in the treatment of schizophrenia. These authors showed a
G. DAVIS GAMMON, HISHAM HAFEZ, JOHN P. DOCHERTY. Chlorpromazine and Immunologic Considerations of Schizophrenia. Ann Intern Med. 1980;92:441–442. doi: 10.7326/0003-4819-92-3-441_2
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Published: Ann Intern Med. 1980;92(3):441-442.
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