ROBERT D. BRANDSTETTER, M.D.; DEXTER D. MAR, PHARM. D.
To the editor: In his otherwise excellent review of ibuprofen (1), Dr. Kantor has omitted adverse renal side effects when he discusses this drug's adverse effects. Over the last 2 years, significant attention has been directed towards deterioration of renal function caused by nonsteroidal anti-inflammatory drugs, including ibuprofen (2-5). The mechanism of the renal dysfunction is believed to involve renal prostaglandin synthetase inhibition with resulting alteration in renal hemodynamics (2).
BRANDSTETTER RD, MAR DD. Side Effects of Ibuprofen. Ann Intern Med. 1980;92:569–570. doi: 10.7326/0003-4819-92-4-569_3
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Published: Ann Intern Med. 1980;92(4):569-570.
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