ISRAEL POTASMAN, M.D.; HARRY BASSAN, M.D.
To the editor: A 65-year-old woman suffering from hypothyroidism and ischemic heart disease was admitted with hemoptysis and breathlessness found to be due to pulmonary embolism. Treatment was commenced with heparin and nicoumalone (a warfarin derivative). Within the first 4 days she received a total of 32 mg of nicoumalone, and satisfactory levels of prothrombin time were achieved. On the fifth day the prothrombin time was 26 s (control, 9.7 s). On the following day, proven urinary tract infection necessitated the administration of nalidixic acid. The drug was given in a daily dose of 1 g.
Quite unexpectedly a further
POTASMAN I, BASSAN H. Nicoumalone and Nalidixic Acid Interaction. Ann Intern Med. ;92:571. doi: 10.7326/0003-4819-92-4-571_1
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Published: Ann Intern Med. 1980;92(4):571.
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