JOHN L. BOICE, M.D.
To the editor: In laboratory animals, two conditions are necessary to enhance the susceptibility to overwhelming pneumococcal infection after intraperitoneal inoculation: absence of the spleen; and absent or limited amounts of pre-existing antipneumococcal opsonizing antibody (1). Winston and colleagues (2) elegantly demonstrate in their paper in the December 1979 issue impaired serum opsonic activity secondary to low specific serum antibody or low complement activity in six of seven long-term bone marrow transplant survivors with episodes of severe pneumococcal infection. They speculate on several possible causes for these findings including immunologic immaturity secondary to therapy, absence of splenic production of specific
BOICE JL. Pneumococcal Infection in Bone Marrow Transplant Recipients. Ann Intern Med. ;92:571. doi: 10.7326/0003-4819-92-4-571_2
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Published: Ann Intern Med. 1980;92(4):571.
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