SALLY D. LANE, M.D.; EMMANUEL C. BESA, M.D.; ROSALINE R. JOSEPH, M.D.
To the editor: The antiestrogen tamoxifen is frequently used in the treatment of metastatic breast cancer and has been considered relatively nontoxic. We wish to report two cases pertinent to this point.
The first patient was a 48-year-old woman with breast cancer metastatic to bone. She was surgically post-menopausal, and estrogen receptors were positive in the primary tumor specimen. One week after beginning tamoxifen, 10 mg twice a day, serum calcium concentration rose from 9.9 mg/dL to 18.5 mg/dL. She was treated with saline hydration, intravenous furosemide, and mithramycin. Tamoxifen was discontinued. Serum calcium returned to normal within 3 days.
LANE SD, BESA EC, JOSEPH RR. Tamoxifen and Hypercalcemia. Ann Intern Med. ;92:572–573. doi: 10.7326/0003-4819-92-4-572_2
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Published: Ann Intern Med. 1980;92(4):572-573.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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