GARY L. LATTIMER, M.D.
To the editor: During the past 2 years, evidence has been accumulated to suggest that the indirect fluorescent antibody (FA) test for diagnosing Legionnaires' disease lacks specificity (1-4). Results of indirect FA staining of Legionella pneumophila serogroup 1 and the "Legionella-like agents" TATLOCK, HEBA, and WIGA, reported by Hébert and colleagues (5), further document the nonspecificity of this test. Even though the last three agents are not genetically related to L. pneumophila, convalescent sera from guinea pigs infected with TATLOCK, HEBA, and WIGA gave distinct staining of L. pneumophila. However, guinea pigs infected with L. pneumophila did not stain TATLOCK
LATTIMER GL. Legionnaires' Disease: Indirect Fluorescent Antibody Test in Diagnosis. Ann Intern Med. ;92:708. doi: 10.7326/0003-4819-92-5-708_1
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Published: Ann Intern Med. 1980;92(5):708.
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