RANDY LINDE, M.D.; HARRISON J. SHULL, M.D.; SAM MARNEY, M.D.; PETER W. STACPOOLE, PH.D., M.D.; DAVID RABIN, M.D.
To the editor: Recent reports have detailed the effectiveness of H2 receptor antagonist therapy (1, 2) in the treatment of gastric hypersecretion and diarrhea in systemic mastocytosis. We report another such case in which normal bowel habits returned after treatment with H1 and H2 blocking agents, suggesting that her diarrhea was due to excessive release of mast-cell histamine.
A 61-year-old white woman was admitted to Vanderbilt University Hospital in May 1978 because of profuse watery diarrhea. In January 1978, she developed continuous watery diarrhea with as many as 20 bowel movements daily. She denied flushing, headache, dizziness, or palpitations and
LINDE R, SHULL HJ, MARNEY S, STACPOOLE PW, RABIN D. Combination H1 and H2 Receptor Antagonist Therapy in Mastocytosis. Ann Intern Med. ;92:716. doi: 10.7326/0003-4819-92-5-716_2
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Published: Ann Intern Med. 1980;92(5):716.
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