HUNTER HEATH III, M.D.
To the editor: Fogelman and colleagues (1) show increased total-body retention of technetium-99m diphosphonate in a small group of patients with primary hyperparathyroidism and equate this finding with evidence of "skeletal disease." They propose this as a ". . . simple, sensitive . . . test in the diagnosis and evaluation of . . . suspected primary hyperparathyroidism." In my opinion, their logic is flawed and their conclusions premature, if not inappropriate. Several specific criticisms follow.
1. The authors state that their method "can differentiate patient groups with renal osteodystrophy, osteomalacia, Paget's disease, and primary hyperparathyroidism from a control population"
HUNTER HEATH. Technetium-99m Diphosphonate Retention in Hyperparathyroidism. Ann Intern Med. 1980;92:873–874. doi: 10.7326/0003-4819-92-6-873
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Published: Ann Intern Med. 1980;92(6):873-874.
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