MARTIN SHANSKY, M.D.; CAL W. GREENLAW, PHARM.D.
To the editor: Numerous case reports have implicated penicillin, its derivatives, and cephalosporins in causing infrequent neutropenia (1-3). DiCato and Ellman (4) reported four cases of granulocytopenia secondary to cephalothin in their institution during a 1-year period and suggested an incidence of 0.1%. Homayouni and colleagues (1) reported leukopenia in two patients receiving cephalothin and two receiving cefamandole. In a study of cefoxitin efficacy for pelvic infections, White and coworkers (5) briefly mention a patient who developed transient neutropenia secondary to cefoxitin therapy. This case appears to be the only one the medical literature of neutropenia as a complication of
SHANSKY M, GREENLAW CW. Reversible Acute Leukopenia and Cefoxitin. Ann Intern Med. ;92:874–875. doi: 10.7326/0003-4819-92-6-874_3
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Published: Ann Intern Med. 1980;92(6):874-875.
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