WILSON S. COLUCCI, M.D.; GORDON H. WILLIAMS, M.D.; EUGENE BRAUNWALD, M.D.
Although it is generally agreed that the first administration of prazosin to patients with severe heart failure increases cardiac output and reduces venous pressure by relaxing vascular smooth muscle, there is much controversy over the drug's continued activity during chronic administration. Thus, some investigators have noted rapid tolerance to prazosin's vasodilator action and little or no chronic effectiveness (1, 2), whereas others have found a continued long-term hemodynamic and clinical response to the drug (3, 4). The reason(s) for this wide disparity of findings is unclear but may involve the degree to which various neurohumoral mechanisms are activated (5, 6).
COLUCCI WS, WILLIAMS GH, BRAUNWALD E. Increased Plasma Norepinephrine Levels During Prazosin Therapy for Severe Congestive Heart Failure. Ann Intern Med. ;93:452–453. doi: 10.7326/0003-4819-93-3-452
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Published: Ann Intern Med. 1980;93(3):452-453.
Cardiology, Heart Failure.
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