WENDY E. HOY, M.B., B.S.; ALEJANDRO RIVERO, M.D.; MATTHEW G. MARIN, M.D.; FREDRIC RIEDERS, Ph. D.
Hemoperfusion with Amberlite XAD-4 resin (X-R004 cartridge; Extracorporeal Medical Specialties, Inc., King of Prussia, Pennsylvania) (1) removes meprobamate from plasma and produces better drug clearance than does charcoal hemoperfusion (2). We report here two life-saving XAD-4 hemoperfusions in a patient with a massive meprobamate overdose in which the efficient calculated extraction of drug was confirmed by subsequent recovery of a large quantity of meprobamate from the used cartidges.
A 39-year-old man ingested 200 g of meprobamate and a quantity of other drugs. His stomach contained many pill fragments, and charcoal slurry and magnesium citrate were instilled. He became comatose and
HOY WE, RIVERO A, MARIN MG, RIEDERS F. Resin Hemoperfusion for Treatment of a Massive Meprobamate Overdose. Ann Intern Med. ;93:455–456. doi: 10.7326/0003-4819-93-3-455
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Published: Ann Intern Med. 1980;93(3):455-456.
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